Sunday, January 31, 2010

Effect of Fermented Chub Mackerel Extract on Lipid Metabolism of Diabetic Rats

1Departement of Animal Science, Faculty of Agriculture, Bengkulu University, Bengkulu, Indonesia.
2Laboratory of Animal Nutrition, Division of Bioresources and Bioproduction, Graduate School of Agriculture, Hokkaido University, Sapporo 060-0809, Japan

The present study was conducted to evaluate the effect of fermented chub mackerel extract (FCME) on lipid metabolism in diabetic rats. Four week-old male Wistar rats were divided into three groups based on weight. All rats were induced with diabetes mellitus by single intraperitoneal injection of streptozotocin at 45 mg/kg body weight. Thereafter, they were randomly distributed to three treatments with 7 rats assigned to each treatment. One group was the control with no additive, and two-treatment groups were given the purified diets supplemented with 1% or 2% FCME. Experimental results showed that in comparison with the control, diabetic rats fed FCME increased feed intake (p<0.01) and body weight gain (p<0.05). FCME inclusion significantly reduced the activities of acetyl-CoA carboxylase (p<0.01) and fatty acid synthetase (p<0.05) in diabetic rats. FCME significantly increased cholesterol 7-hydroxylase with no effect on HMG-CoA reductase activity. FCME had no effect on hepatic triglyceride, free cholesterol and phospholipid. FCME inclusion at 1% level significantly reduced serum triglyceride. FCME significantly increased HDL-cholesterol (p<0.05) with no effect on LDL + VLDL-cholesterol, and significantly reduced atherogenic index. FCME did not significantly affect serum insulin and glucose concentration. In conclusion, FCME supplementation altered lipid metabolism in diabetic rats. FCME supplementation reduced the risk of atherosclerosis in diabetic rats.

Key words: Fermented chub mackerel extract, lipid metabolism, diabetic rat

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