Friday, April 15, 2011

Effect of fermented chub mackerel extract on lipid metabolism of rats fed diets without cholesterol

U. Santoso*, S. Ishikawa and K. Tanaka
Laboratory of Animal Nutrition, Division of Bioresources and Bioproduction, Graduate School of Agriculture, Hokkaido University, Sapporo 060-0809, Japan
*Department of Animal Science, Faculty of Agriculture, Bengkulu University, Bengkulu Indonesia
Abtract. The present study was conducted to evaluate the effect of fermented chub mackerel extract (FCME) on lipid metabolism in rats fed diets without cholesterol. Four week-old male rats were divided into three groups of 10 rats with 0, 1 or 2% FCME supplementation to the diets. Ourified diets were used in the present study. Feed and water were fed ad libitum. FCME supplementation had no effect on the activities of acetyl-CoA carboxylase, fatty acid synthetase, and the content of free cholesterol, triglyceride and phospholipids in the liver (P>0.05). 1% FCME supplementation significantly increased serum triglyceride (P<0.05) and hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity (P<0.05) with no effect on serum total cholesterol, free cholesterol and phospholipids concentration. FCME supplementation significantly reduced serum LDL+VLDL-cholesterol (P<0.01) and atherogenic index (P<0.01) with no effect on HDL-cholesterol. The current study showed that FCME inclusion might reduce the risk of atherosclerosis in rats fed diet without cholesterol (Asian-Australasian Journal of Animal Science, 2001, 14 (4): 535-539.
Key words: Fermented chub mackerel extract, lipid metabolism, rats

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