Thursday, April 14, 2011

Effect of fermented chub mackerel extract on lipid metabolism of rats fed a high-cholesterol diet

U. Santoso*, S. Ishikawa and K. Tanaka
Laboratory of Animal Nutrition, Division of Bioresources and Bioproduction, Graduate School of Agriculture, Hokkaido University, Sapporo 060-0809, Japan
*Department of Animal Science, Faculty of Agriculture, Bengkulu University, Bengkulu Indonesia

Abstract. The present study was conducted to evaluate effect of fermented chub mackerel extract (FCME) on lipi metabolism of rats fed a diet supplemented wit 1% cholesterol. Four week-old male rats were divided into three groups of 15 rats with 0, 1% or 2% FCME supplementation. In comparison with control, rats fed 2% FCME showed reduction of activities of acetyl-CoA carboxylase (P<0.05), 3-hydroxy-3-methylglutaryl-CoA reductase (P<0.01) and fatty acid synthetase (P<0.01). Rats fed 2% FCME also showed reduction in free cholesterol in the liver (P<0.05), and in the concentration of free cholesterol (P<0.05), LDL+VLDL-cholesterol (P<0.05), triglyceride (P<0.01) and phospholipids (P<0.01 in the plasma. Plasma HDL-cholesterol concentration was significantly (P<0.05) higher in treatment groups as compared with control group. Atherogenic index was also significantly lower in rats fed 1% or fed 2% supplemented diet, whereas bile acid in feces was not significantly affected. The current study showed that 2% inclusion level of fermented chub mackerel extract might have hypolipidemic properties (Asian-Australasian Journal of Animal Science, 2000, 13 (4): 516-520.
Key words: Fermented chub mackerel extract, hig cholesterol diet, lipid metabolism, atherogenic index

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